TDP-43 loss induces cryptic polyadenylation in ALS/FTD

by Clinical Neuropsychologist | Tuesday, October 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02050-wThe authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different...

TDP-43 loss brings RNA to a twist ending

by Clinical Neuropsychologist | Tuesday, October 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02065-3In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent...

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

by Clinical Neuropsychologist | Monday, October 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 October 2025; doi:10.1038/s41593-025-02074-2Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a...

A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses

by Clinical Neuropsychologist | Monday, October 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 October 2025; doi:10.1038/s41593-025-02078-yFigge-Schlensok et al. show that leptin-sensitive neurons in the lateral hypothalamus encode anxiogenic stimuli and facilitate adaptive strategies to enable an animal to overcome...

Differential synaptic depression mediates the therapeutic effect of deep brain stimulation

by Clinical Neuropsychologist | Thursday, October 16, 2025 | Neuroscience

Nature Neuroscience, Published online: 16 October 2025; doi:10.1038/s41593-025-02088-wThe authors show that deep brain stimulation (DBS) inhibits local neural activity via differential suppression of glutamate and GABA release, and they developed a chemogenetic...

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS

by Clinical Neuropsychologist | Tuesday, October 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 October 2025; doi:10.1038/s41593-025-02075-1This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways...