Aging and injury drive neuronal senescence in the dorsal root ganglia

by Clinical Neuropsychologist | Wednesday, May 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 May 2025; doi:10.1038/s41593-025-01954-xThe authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain. If you do not see...

Activity-driven myelin sheath growth is mediated by mGluR5

by Clinical Neuropsychologist | Wednesday, May 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 May 2025; doi:10.1038/s41593-025-01956-9Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling...

Bilateral integration in somatosensory cortex is controlled by behavioral relevance

by Clinical Neuropsychologist | Wednesday, May 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 May 2025; doi:10.1038/s41593-025-01960-zHow sensory signals from both sides of the body are integrated into a single percept is not well understood. Park et al. show that callosal signaling supports the integration of...

MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types

by Clinical Neuropsychologist | Monday, May 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 May 2025; doi:10.1038/s41593-025-01947-wNeuron-specific DNA methylation and intragenic enhancers target the Rett syndrome protein methyl-CpG-binding protein 2 to regulate genes that delineate closely related neuron types,...

Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways

by Clinical Neuropsychologist | Monday, May 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 May 2025; doi:10.1038/s41593-025-01951-0Social status mediates individual differences in methamphetamine-seeking by modulating dopaminergic pathways. In subordinate rodents, the mesolimbic pathway is stronger, and the...

Widespread brain–body integration during changes of arousal

by Clinical Neuropsychologist | Friday, May 9, 2025 | Neuroscience

Nature Neuroscience, Published online: 09 May 2025; doi:10.1038/s41593-025-01946-xWidespread, slow fluctuations in brain blood flow detected via functional MRI and neural activity are integrated with systemic physiological dynamics across the body. We showed this...