Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01784-3The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and...

The BRAIN initiative: a pioneering program on the precipice

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01811-3Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric...

The cell-type underpinnings of the human functional cortical connectome

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01812-2Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01801-5Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s...

Converging cortical axes

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01722-3The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular specializations to macroscale functional networks. Zhang et al....

A top-down slow breathing circuit that alleviates negative affect in mice

by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Neuroscience

Nature Neuroscience, Published online: 19 November 2024; doi:10.1038/s41593-024-01799-wJhang et al. identify a prefrontal–pontomedullary pathway that slows breathing and reduces anxiety in mice, where the pontine reticular nucleus converts excitatory prefrontal inputs...