by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Dementia
Abstract INTRODUCTION MicroRNAs are short non-coding RNAs that control proteostasis at the systems level and are emerging as potential prognostic and diagnostic biomarkers for Alzheimer’s disease (AD). METHODS We performed small RNA sequencing on plasma samples...
by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Dementia
Abstract INTRODUCTION MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer’s disease (AD) pathogenesis. METHODS We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer’s...
by Clinical Neuropsychologist | Tuesday, September 17, 2024 | Dementia
Abstract INTRODUCTION We aimed to evaluate the feasibility of the 2024 Alzheimer’s Association Workgroup’s integrated clinical-biological staging scheme in outpatient settings within a tertiary memory clinic. METHODS The 2018 syndromal cognitive staging...
by Clinical Neuropsychologist | Tuesday, September 17, 2024 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) initiates years prior to symptoms, underscoring the importance of early detection. While amyloid accumulation starts early, individuals with substantial amyloid burden may remain cognitively normal, implying that...
by Clinical Neuropsychologist | Monday, September 16, 2024 | Dementia
Abstract This paper for the 20th anniversary of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe (MTL) subregions in ADNI using a dedicated high-resolution T2-weighted...