by Clinical Neuropsychologist Online | Tuesday, April 23, 2024 | Dementia
Abstract INTRODUCTION We investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the WMH-connected cortex using multimodal images. METHODS We included 107...
by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Abstract INTRODUCTION We assessed a genetic risk score for Alzheimer’s disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial. METHODS 1260 at-risk older individuals without dementia were randomized to...
by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Dementia, Volume 23, Issue 6, Page 964-980, August 2024. ObjectiveThe main aim of this study was to evaluate the feasibility and acceptability of using a GPS tracker to mitigate the risks associated with wandering for people with dementia and those caring for them and...
by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Abstract INTRODUCTION We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI). METHODS Participants aged 65-85 years with MCI were randomized into intervention (management...
by Clinical Neuropsychologist Online | Monday, April 22, 2024 | Dementia
Abstract INTRODUCTION We investigate pathological correlates of plasma phosphorylated tau 181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) across a clinically diverse spectrum of neurodegenerative disease, including normal...
