by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia
Abstract BACKGROUND Polypharmacy, potentially inappropriate medications (PIMs), and drugs associated with drug-induced cognitive impairment (DICI) are highly prevalent in older adults and may affect cognitive decline. METHODS This observational retrospective study...
by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia
Abstract BACKGROUND Vascular and glymphatic dysfunction are increasingly implicated in Alzheimer’s disease (AD), particularly among apolipoprotein E (APOE) ε4 carriers. We investigated relationships among retinal microvasculature, glymphatic markers, and AD...
by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is a leading cause of lobar intracerebral hemorrhage (ICH) in the elderly. The influence of apolipoprotein E (APOE) variants, CAA pathology, and concomitant Alzheimer’s disease (AD) neuropathologic changes...
by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia
Abstract INTRODUCTION Dementia is a public health challenge and exposures likely contribute to risk, though many have not been evaluated. We screened chemicals for enrichment with dementia genes and related pathways. METHODS We obtained gene lists from Agora and the...
by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia
Abstract INTRODUCTION Sleep is a modifiable risk factor in Alzheimer’s disease (AD), but its relationship to medial temporal lobe (MTL) subfields and responsiveness to lifestyle interventions remain unclear. METHODS In the Dementia-Multi-Objective Validation of...
