by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Dementia
Abstract INTRODUCTION Extreme heat is increasingly recognized as a significant threat to brain health. However, human evidence from large, longitudinal studies remains limited. We examine whether outdoor heat exposure is associated with incident dementia and whether...
by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Dementia
Abstract INTRODUCTION It remains unclear whether medial temporal lobe (MTL) hyperperfusion in cognitively unimpaired apolipoprotein E (APOE) ɛ4 carriers reflects resilience or dysfunction. We examined whether cortical MTL cerebral blood flow (CBF) relates to cognition...
by Clinical Neuropsychologist Online | Wednesday, October 21, 2026 | Dementia
Abstract Depression and Alzheimer’s disease (AD) frequently overlap clinically, and depressive symptoms may signal major depressive disorder, a risk factor for AD, or an early manifestation of neurodegeneration. This scoping review mapped biomarker evidence...
by Clinical Neuropsychologist Online | Tuesday, October 20, 2026 | Dementia
Abstract INTRODUCTION Plasma phosphorylated tau (p-tau)217 is increasingly used to triage amyloid testing, but the biological and clinical meaning of discordant plasma p-tau217 and amyloid positron emission tomography (PET) results in cognitively normal adults remains...
by Clinical Neuropsychologist Online | Tuesday, October 20, 2026 | Dementia
Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer’s disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3...
