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Integrated digit‐in‐noise testing for hearing and cognitive screening

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Hearing loss and cognitive decline often coexist in aging, and reduced audibility can bias cognitive screening. We evaluated integrated digit-in-noise (iDIN) testing for paired screening. METHODS Among 962 community-screened adults 55 years of...

Aberrant ɑSMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Neural network and bioenergetic abnormalities occur with Alzheimer’s disease (AD) pathogenesis. METHODS We explored mossy fiber (MF) and mitoenergetic alteration using ɑ-smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX)...

The effects of bariatric surgery on dementia in patients with diabetes and obesity

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Type 2 diabetes (T2D) and obesity are among the most important risk factors for dementia. Although weight loss is an important preventive strategy, the impact of metabolic and bariatric surgery (MBS) on dementia risk remains contradictory....

A combined artificial intelligence–wet lab approach identifies a pivotal role of the NAD+–mitophagy axis on aging and neurodegeneration

by Clinical Neuropsychologist Online | Friday, August 21, 2026 | Dementia

Abstract INTRODUCTION Emerging evidence points to a role of nicotinamide mononucleotide (NAD+) depletion and compromised mitophagy in aging and neurodegenerative diseases. We hypothesize that age-dependent impairment of the NAD+–mitophagy axis contributes to brain...

Serum sodium, tonicity, and risk of dementia in cohort and healthcare populations

by Clinical Neuropsychologist Online | Thursday, August 20, 2026 | Dementia

Abstract INTRODUCTION Identifying modifiable, accessible dementia risk factors is critical for prevention. Worldwide surveys indicate that about half of adults do not meet recommended fluid intake and may be chronically underhydrated. METHODS We examined associations...
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