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Beyond Seizures: The hidden burden of fatigue in epilepsy

by Clinical Neuropsychologist | Tuesday, November 25, 2025 | Neuroscience

Objectives: To determine the prevalence of fatigue and depression in patients with epilepsy (PWE), explore their relationship, and identify the factors associated with fatigue in this population. Methods: This retrospective cross-sectional study involved adult PWE at...

50 Years of Busting Myths About Aging in the Brain

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

CNS 2026 Q&A with Carol Barnes When Carol Barnes turned 65 years old, she had a stunning realization: that she was now the people, 65 years and older, she had been studying for the past several decades – and – that she was “OK.”  Reflecting several years later on...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02117-8Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for...

Munc18 modulates syntaxin phase separation to promote exocytosis

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02140-9Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that...

A mouse brain atlas based on dendritic microenvironments

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02119-6The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also...
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