Experiences of Indonesian people with dementia and carers undertaking an online-delivered exercise program

by Clinical Neuropsychologist Online | Monday, February 26, 2024 | Dementia

Dementia, Volume 23, Issue 4, Page 584-609, May 2024. Participating in physical activity is beneficial for older people with dementia. Little is known however about the perceptions of people living with dementia undertaking an online-delivered exercise program. This...

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer’s Disease Research

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer’s Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address...

Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Increasing evidence suggests that amyloid reduction could serve as a plausible surrogate endpoint for clinical and cognitive efficacy. The double-blind phase 3 DIAN-TU-001 trial tested clinical and cognitive declines with increasing doses of...

Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Individuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia-related neuropathologies is unknown. METHODS This cross-sectional study...

Patient‐ and proxy‐reported quality of life in advanced dementia with Lewy bodies

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Little is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages. METHODS Dyads of individuals with moderate–advanced DLB and their primary caregivers were recruited from specialty clinics,...

Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION We investigated whether retinal capillary perfusion is a biomarker of cerebral small vessel disease and impaired cognition among Black Americans, an understudied group at higher risk for dementia. METHODS We enrolled 96 Black Americans without...