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Anxiety in Alzheimer’s disease rats is independent of memory and impacted by genotype, age, sex, and exercise

by Clinical Neuropsychologist | Tuesday, April 16, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) is characterized by cognitive impairments; however, heightened anxiety often accompanies and, in some cases, exacerbates cognitive its. The present study aims to understand the influence of multiple variables on...

Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results

by Clinical Neuropsychologist | Tuesday, April 16, 2024 | Dementia

Abstract INTRODUCTION Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in...

The impact on employment and education of caregiving for a family member with young onset dementia: A scoping review

by Clinical Neuropsychologist | Tuesday, April 16, 2024 | Dementia

Dementia, Volume 23, Issue 5, Page 850-881, July 2024. Young-onset dementia (YOD) affects individuals under 65 years of age, often leading to loss of employment and independence. Families provide increasing levels of care to family members with YOD, resulting in...

Progressive reduction of nuclear receptor Nr4a1 mediates age‐dependent cognitive decline

by Clinical Neuropsychologist | Friday, April 12, 2024 | Dementia

Abstract INTRODUCTION Cognitive decline progresses with age, and Nr4a1 has been shown to participate in memory functions. However, the relationship between age-related Nr4a1 reduction and cognitive decline is undefined. METHODS Nr4a1 expressions were evaluated by...

Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study

by Clinical Neuropsychologist | Thursday, April 11, 2024 | Dementia

Abstract INTRODUCTION We investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study. METHODS Participants self-reported sleep duration and underwent neuropathologic...
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